Research

Research is an integral part of the Division of Hematology at the University of Utah with the robust research programs of past division chiefs, including Maxwell Wintrobe, George Cartwright, Jack Athens, and James Kushner laying this foundation of excellence. Physicians and basic scientists participate in a broad range of multidisciplinary research into malignant and non-malignant hematological disorders with the goals of understanding the basic biology of these disorders and developing therapeutics for improved clinical care of patients. Thus, basic and translational research programs exist within the division.

Hematology faculty are training the next generation of basic, clinical and translational investigators. Last year faculty from our division were awarded $1,751,000 in extramural grant income; this is one indicator of the successful research programs within the division.

Basic Research

Basic research is focused on:

  • Elucidating the molecular basis of congenital and acquired polycythemia
  • Characterizing mechanisms of drug resistant BCR-ABL tyrosine kinases
  • Hematopoietic stem cell differentiation
  • Defect in erythropoiesis
  • Graft versus host disease in bone marrow transplantation
  • Paroxysmal nocturnal hemoglobinuria
  • Porphyrias
  • Iron homeostasis in multiple model organisms
  • Dysregulation of iron metabolism
  • Mitochondrial functions

Clinical & Translational Research Programs

Clinical and Translational research programs include:

  • Control of the allogeneic immune response in post-transplant patients
  • Therapeutics for porphyrias
  • Novel therapeutics of hematologic malignancies including chronic myeloid leukemia, acute myeloid leukemia and myeloproliferative neoplasms
  • Understanding the biology of disease persistence in drug-resistant chronic myeloid leukemia
  • Development of novel therapies for myeloma
  • Trials on new antithrombotic agent

Health Sciences Center Core (HSC) Research Facilities

The HSC operates a number of core facilities that provide advanced technologies to empower basic and clinical research. These core facilities are available to University faculty and researchers. Learn more about the university’s cores.