2017 U-CARS Highlights
Once again, attendees from around the world participated in the 5th Annual Utah Cardiac Recovery Symposium (U-CARS), which was held on January 12-13, 2017 at the University of Utah School of Medicine in scenic Salt Lake City, UT.
The keynote address was delivered by Valentin Fuster, MD, PhD, Physician-in-Chief, Mount Sinai Hospital and Director, Mount Sinai Cardiovascular Institute. Dr. Fuster is also Editor-in-Chief of JACC.
The 2017 symposium attracted over 450 attendees, sparked in-depth discussions and featured ground-breaking research from around the globe in the field of cardiac recovery.
Agenda
Thursday, January 12, 2017
9:00 - 11:00am
Session 1: Defining Myocardial Recovery
Chairpersons: James Fang, MD, U of Utah, Salt Lake City and Donald Lappe, MD, Intermountain Medical Center, Salt Lake City
Topic |
Speaker |
1. What is myocardial recovery: basic, translational and clinical perspective? |
Douglas Sawyer, MD, PhD, |
2. NHLBI Working Group: “Advancing the science of myocardial recovery |
Frank Pagani, MD, PhD, |
3. How to leverage registries and big data to advance the field of cardiac recovery. |
James K. Kirklin, MD, |
4. “AHA HF Strategically Focused Research Network”: opportunities and challenges. |
Craig Selzman, MD, |
11:00 - 11:45am
KEYNOTE ADDRESS:
The Highlight of the Current Cardiology: A Movement from Disease to Health
Valentin Fuster, MD/PhD
Physician-in-Chief, Mount Sinai Hospital, New York, NY
Director, Mount Sinai Cardiovascular Institute, New York, NY
Editor-in-Chief JACC
LUNCH AND POSTER VIEWING: 11:45am - 12:45pm
12:45 -2:45pm
Session 2: New Approaches to Achieve Cardiac Recovery
Chairpersons: Dean Li, MD, PhD, U of Utah, Salt Lake City and E. Dale Abel, MD, PhD, U of Iowa, Iowa City
Topic |
Speaker |
1. Targeting Ca-Cycling in Heart Failure: Promises and Challenges. |
Evangelia G. Kranias, PhD, University of Cincinnati, Cincinnati, OH |
2. Epigenetic Control of mTOR in Cardiovascular Disease. |
Joseph Hill, MD, PhD, UT Southwestern, Dallas, TX |
3. Intercalated disc proteins, CAR and Z01, in cardiac function and conduction |
Kirk Knowlton, MD, Intermountain Healthcare, Salt Lake City, UT |
4. Overcoming challenges to the practical application of precision |
Martin Tristani-Firouzi, MD, U of Utah/Primary Children’s/CVRTI, Salt Lake City, UT |
BREAK -2:45 - 3:00pm
3:00 - 4:30pm
Session 3: Right Heart Failure and Recovery
Chairpersons: Stephen McKellar, MD, U of Utah, Salt Lake City and Joshua Zimmerman, MD, U of Utah, Salt Lake City
Topic |
Speaker |
1. Right Ventricular Recovery and Other Novel Targets in Pulmonary Hypertension Clinical Trials. |
John Ryan, MD, U of Utah, Salt Lake City, UT |
2. Role of aldosterone in pulmonary hypertension. |
Bradley A. Maron, MD, Brigham and Women's Hospital, Boston, MA |
3. RV failure and mechanical circulatory support. |
Jonathan Rich, MD, Northwestern University, Chicago, IL |
4:30 - 6:00pm
Session 4: Defining the Role of Periphery in Heart Failure and Recovery
Chairpersons: Lillian L. Khor, M.B.B.Ch., M.Sc., U of Utah, Salt Lake City and Adrianna Torres Navas, MD, Fundacion Cardioinfantil, Bogota, Colombia
Topic |
Speaker |
1. Skeletal muscle oxygen uptake and utilization in |
Tim Musch, PhD, Kansas State University, Manhattan, KS |
2. Peripheral vascular function in heart failure and |
Walter Wray, PhD, U of Utah, Salt Lake City, UT |
3. Peripheral vascular pulsatility and function in |
Russell S. Richardson, PhD, U of Utah & VA Medical Center, Salt Lake City, UT |
7:00 - 9:30 pm
Symposium Dinner
Friday, January 13, 2017
7:00 - 7:55am
Sunrise Session: Oral Presentation of Best Abstracts
Chairpersons: Edward Michael Gilbert, MD, U of Utah, Salt Lake City, UT and Jose Nativi-Nicolau, MD, U of Utah, Salt Lake City, UT
Topic |
Speaker |
1. Impella 2.5 and CP Use at a Rural Community Hospital; Experience and Outcomes with 97 Implants 2011-2016 |
Charles Wilkins, MD, San Juan Regional Hospital, Farmington, NM |
2. Profiling plasma caspase activity in heart failure and during LVAD support as biomarkers of cardiac health and recovery. |
Frank Jefferson, MD, Duke University, Durham, NC |
3. Peripheral vascular pulsatility in heart failure patients with continuous flow centrifuge and axial left ventricular assist devices: the effect of pump speed. |
Jay Hydren, MS, University of Utah, Salt Lake City, UT |
4. Cerebral autoregulation and brain-tissue oxygenation are preserved in patients with continuous-flow left ventricular assist devices. |
William K. Cornwell III, MD, University of Colorado, Aurora, CO |
5.Scientific considerations: accuracy, physiology, details (the devil lives here). |
Alan Morris, MD, U of Utah/Intermountain Healthcare, Salt Lake City, UT |
8:00 - 10:15am
Session 5: Mechanical Unloading and Recovery: Moving Forward
Chairpersons: John Spertus, MD, MPH, University of Missouri, Kansas City and J. Timothy Baldwin, PhD, National Heart, Lung, and Blood Institute, Bethesda, Maryland
Topic |
Speaker |
1. Mechanical unloading and cardiac recovery 20 years later: opportunities and challenges. |
A.G. Kfoury, M.D., Intermountain Healthcare, Salt Lake City, UT |
2. Optimal type and degree of mechanical unloading: bioengineering perspective. |
Stephen M. Koenig, MD, U of Louisville, Louisville, KY |
3. Advanced imaging technologies enlightening our perspectives. |
Linda R. Peterson, MD, Washington University, St. Louis, MO |
4. Connecting clinical factors and biology to patient health status in recovery. |
Josef Stehlik, MD, MPH, U of Utah, Salt Lake City, UT |
5. RESTAGE-HF: A North American multicenter trial reviving the field |
Emma Birks, MD, U of Louisville, Louisville, KY |
BREAK: 10:15- 10:30am
10:30am-12:30pm
Session 6: Mechanical Unloading and Recovery: the Utah Cardiac Recovery Program (UCAR) Approach
Chairpersons: Joseph Hill, MD, PhD, UT Southwestern, Dallas and Evangelia G. Kranias, PhD, U of Cincinnati, Cincinnati
Topic |
Speaker |
1. UCAR: clinical and translational perspective. |
Stavros Drakos, MD, PhD, U of Utah, Salt Lake City, UT |
2. Investigating recovery: from the tissue harvest, to the echo lab, to the patient. |
Omar Wever-Pinzon, MD, U of Utah, Salt Lake City, UT |
3. Understanding cellular and microstructural remodeling through UCAR |
Frank Sachse, PhD, U of Utah/CVRTI, Salt Lake City, UT |
4. Utilizing UCAR to probe the human proteome. |
Sarah Franklin, PhD, U of Utah /CVRTI, Salt Lake City, UT |
LUNCH: 12:30 - 1:30pm
1:30 - 3:30pm
Session 7: Oral presentations of best abstracts
Chairpersons: Alejandro Bertolotti, MD, Fundacion Favaloro, Buenos Aires, Argentina and Josef Stehlik, MD, MPH, U of Utah, Salt Lake City
Featured presentation:
Use of MCS to achieve myocardial recovery after primary graft failure. Juan Mejia, MD, Messejana Hospital, Fortaleza, Brazil
Topic |
Speaker |
1. Gene expression in Pediatric Myocardium: Pulsatile- vs. Continuous-Flow VAD Support. | Iki Adachi, MD, Baylor College of Medicine, Houston, TX |
2. Novel trends in speckle tracking echocardiography in non-ischemic cardiomyopathy patients with heart failure with recovered ejection fraction. |
Stanley Swat, MD, Northwestern University Feinberg School of Medicine, Chicago, IL |
3. Coronary vascular function is improved in ischemic cardiomyopathy patients after continuous-flow left ventricular assist device (LVAD) implantation. | John David Symons, PhD, U of Utah, Salt Lake City, UT |
4. Evidence that Mesenchymal to Endothelial Transition (MET) occurs Secondary to Cardiac Unloading through LVAD support |
Ana Sofia Cruz Solbes, MD, Houston Methodist Hospital, Houston, TX |
5. Effects of increased myocardial tissue concentration of myristic, palmitic and palmitoleic acids on the course of cardiac atrophy of the failing heart unloaded by heterotopic transplantation. |
Martin Pokorný, MD, Institute for Clinical and Experimental Medicine, Prague, Czech Republic |
6. The Effect of Reverse Remodeling on Intraventricular Flow in the LVAD-Supported Heart Studied in a Mock Circulatory Loop. |
Karen May-Newman, PhD, San Diego State University, San Diego, CA |
7. Cardiac spinal sensory endings mediate remodeling in the post MI state. |
Irving H. Zucker, PhD, Editor In Chief, The American Journal of Physiology- Heart and Circulatory Physiology, University of Nebraska, Omaha, NE |
8. Combination Bioelectric Stimulator, Micro Infusion Pump and Multi Protein Composition for Heart Regeneration. |
Leslie Miller, MD, |
3:30 - 5:30pm
Session 8: Acute Heart Failure and Cardiac Recovery
Chairpersons: Fred Welt, MD, U of Utah, Salt Lake City and Joseph E. Tonna, MD, U of Utah, Salt Lake City
Topic |
Speaker |
1. Acute in Chronic Heart Failure/INTERMACS 2-3: How to select patients and mechanical support therapeutic strategies? |
Valluvan Jeevanandam, MD, U of Chicago, Chicago, IL |
2. Profound Cardiogenic shock/ INTERMACS 1: From percutaneous VAD and ECMO to the exit |
Pascal Leprince, MD, Pitié Salpêtrière University, Paris |
3. Acute coronary syndromes and shock: focus on salvaging myocardium. |
E. Magnus Ohman, MD, Duke University, Durham, NC |
4. Debate: Cardiogenic shock therapies: Surgical Versus Percutaneous approach |
Christian Bermudez, U Penn, Philadelphia, PA Claudius Mahr, DO, FACC, FESC, University of Washington, Seattle, WA |
Closing Remarks
Faculty Dinner