IMPROVING OUR NATION’S HEART HEALTH: A CONVERSATION WITH NHLBI DIRECTOR, GARY GIBBONS, MD
2019 U-CARS Highlights
On January 17-18, 2019, thought leaders and participants from around the world gathered for the 7th Annual Utah Cardiac Recovery Symposium (U-CARS). The two day symposium was held in a stunning new venue at the University of Utah Cleone Peterson Eccles Alumni House in scenic Salt Lake City, Utah.
Thursday, January 17th's keynote address was delivered by Gary H. Gibbons, MD, Director of the National Heart, Lung and Blood Institute at the National Institutes of Health (NIH). Friday, January 18th's keynote address was delivered by Jeroen J. Bax, MD, PhD, Immediate Past President of the European Society of Cardiology and Professor at Leiden University, The Netherlands.
The 2019 symposium attracted over 600 attendees once again and featured the clinical and translational impact of the impressive results of the multi-center LVAD Bridge-To-Recovery RESTAGE-HF Trial.
Agenda
Thursday, January 17, 2019
8:00 - 8:15am
Opening Remarks
8:15 - 9:15am
Session 1: What is Myocardial Recovery and How to Manipulate it?
Chairpersons: James C. Fang, MD – U of U Health & Donald L. Lappe, MD – Intermountain Healthcare
|
Topic |
Speaker |
|
1. Clinical view. |
Mandeep R. Mehra, MD, FACC, FESC, FRCP – Brigham & Women’s/ Harvard, Boston, MA |
|
2. Basic and translational science view. |
Joseph Wu, MD, PhD - Stanford University, Stanford, CA |
9:15 - 10:00am
KEYNOTE ADDRESS:
Advancing Discovery Science for Public Health Impact
Gary H. Gibbons, MD
Director, National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health (NIH)
10:00 - 11:45am
Session 2: Advancing the Science of Cardiac Recovery with Mechanical Circulatory Support (MCS)
Chairpersons: Emma J Birks, MD, PhD – U of Louisville & Craig Selzman, MD – U of U Health
|
Topic |
Speaker |
|
1. State of the field |
Stavros G. Drakos, MD, PhD, FACC – U of U Health, Salt Lake City, UT |
|
2. MCS and Regenerative Therapies |
Terrence Yau, MD – U of Toronto, Canada |
|
3. NHLBI Strategic Vision and the Myocardial Recovery Field |
Renee Wong, PhD - NHLBI, NIH, Bethesda, MD |
Panel Discussion - Post-RESTAGE Trial era: what are the next steps?
Panelists: Chairs and Speakers
11:45 - 12:45pm
Lunch - Moderated Poster Session (*NON CME accredited)
Moderators: Rami Alharethi, MD – Intermountain Healthcare; Anna Catino, MD – U of U Health; Rashmee Shah, MD – U of U Health
12:45 - 2:45pm
Session 3: Myocardial recovery innovation
Chairpersons: Jared P. Rutter, PhD – U of U Health & Dipayan Chaudhuri, MD, PhD – U of U Health
|
Topic |
Speaker |
|
1. Door to Unloading to Limit Injury and Promote Cardiac Recovery in Acute MI: Bench to Bedside |
Navin K. Kapur, MD – Tufts Medical Center, Boston, MA |
|
2. Epitranscriptomic Mechanisms of Cardiac Recovery. |
Konstantinos Stellos MD – U of Newcastle, England, UK |
|
3. Combining Proteomics and Transcriptomics To Predict Cardiac Recovery in Advanced HF Patients |
Sarah Franklin, PhD – U of U Health, Salt Lake City, UT |
|
4. Myocardial and Peripheral Vasculature during Mechanical Circulatory Support |
Amrut Ambardekar, MD, U of Colorado, Aurora, CO |
|
5. Targeting myocardial recovery in cardiac amyloidosis…! |
Jose N. Nativi-Nicolau, MD – U of U Health, Salt Lake City, UT |
2:45 - 3:10pm
Break
3:10 - 4:30pm
Session 4: Bioengineering and HF Intersection: Building ‘Smart Pump’ to Recover Both the Heart and the Patient
Chairpersons: John Watson, PhD – UCSD & A.G. Kfoury, MD – Intermountain Healthcare
|
Topic |
Speaker |
|
1. ‘Smart pump’: what does the heart need? |
Dan Burkhoff, MD, PhD – Columbia/ CRF, New York, NY |
|
2. ‘Smart pump’: what does the periphery need? |
Ulrich P. Jorde, MD – Montefiore/ Albert Einstein, Bronx, NY |
|
3. 'Smart pump': what does the patient need? |
Nir Uriel, MD – U of Chicago, Chicago, IL |
|
4. ‘Smart pump’: bioengineering perspective. (*Non-CME accredited) |
David J. Farrar, PhD - Abbott, Pleasanton, CA |
4:30 - 5:30pm
'How to...' practical break out sessions:
|
|
How to treat patients during LVAD support, ii) How to serially screen for cardiac recovery iii) Weaning criteria. INTERACTIVE CASES - Emma J Birks, MD, PhD – U of Louisville & Omar Wever-Pinzon, MD – U of U Health |
|
B. |
How to stop the VAD: surgical and percutaneous approaches - INTERACTIVE CASES - Manreet Kanwar, MD -Allegheny MC & Craig H. Selzman, MD - U of U Health |
|
C. |
Patient-centered decision-making: provider and patient perspectives – PATIENTS LIVE PARTICIPATION – Rebecca J. Cogswell, MD – U of Minnesota & Josef Stehlik, MD – U of Utah |
6:30 - 10:00 pm
Symposium Dinner
Rice Eccles Stadium, University of Utah
Friday, January 18, 2019
8:00 - 9:30am
Session 5: Oral Presentation of Best Abstracts (*Non-CME accredited)
Chairpersons: Amanda Vest, MBBS, MPH – Tufts Medical Center, Jack Morshedzadeh, MD - U of U Health, & Anthony Donato, PhD - U of U Health
|
Topic |
Speaker |
|
1. Krüppel-like factor 5 Regulates the miR-30 Family and Promotes Cardiac Dysfunction in Ischemic Cardiomyopathy |
Matthew Hoffman ,MD/ PhD Student, Temple University, Philadelphia, PA |
|
2. Novel Redox Mechanism for Pathological Cardiac Remodeling and Diastolic Dysfunction |
Rajasekaran Namakkal-Soorappan, MD, U of Alabama at Birmingham, AL |
|
3. Systolic left ventricular energy loss assessed by ultrasonic vector flow mapping |
Lixue Yin, MD, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China |
|
4. Reverse Remodeling Effects of Sacubitril/Valsartan: Structural, Functional and Neurohormonal Optimization in Stage C Heart Failure |
Sara Kalantari, MD, U of Chicago, Chicago, IL |
|
5. Clinical implication of volume loading test in patients undergoing left ventricular assist devise support |
Fusako Sera, MD Osaka University, Japan |
|
6. Centrifugal-Flow Ventricular Assist Device Support in Children: |
Iki Adachi, MD, Texas Children's Hospital, Houston, TX |
|
7. Mechanical Unloading-induced Reversal of Myocardial Fibrosis in Advanced Heart Failure Patients |
Rachit Badolia, PhD, |
|
8. Three Year Outcomes of 3 DT-LVAD patients Bridged to Recovery and Explanted |
Esther S. Shao MD, PhD, |
|
9. New Insights into Right Ventricular Function Among Patients with Left Ventricular Assist Devices using High Fidelity Conductance Catheters to Generate Real Time Pressure Volume Loops |
William K. Cornwell III, MD, |
|
10. Recovery of Right Ventricular Function with Intraaortic Balloon Pump Counterpulsation |
Michael Bonios, MD, PhD, Onassis Cardiac Surgery Center, Athens, Greece |
|
11. Assessment of Hemodynamic Changes during Transcatheter Aortic Valve Replacement with Real-Time Pressure-Volume Loops |
Michael Yaoyao Yin MD, U of U, Salt Lake City, UT |
9:30 - 10:15am
KEYNOTE ADDRESS:
Cardiac Resynchronization Therapy: How to Predict Recovery and Outcomes?
Jeroen J. Bax, MD, PhD, FESC
Immediate Past President European Society of Cardiology (ESC)
Leiden University, The Netherlands
10:15 - 11:45am
Session 6: Should The Recovery Field Pay More Attention to the Role of Arrhythmia/ Electrophysiology (EP)?
Chairperson: Ravi Ranjan, MD, PhD – U of U Health & John Day, MD - Intermountain Healthcare
|
Topic |
Speaker |
|
1. EP Looking Beyond Electricity: the Atria as a Pump - Old and New Ideas. |
Stavros Stavrakis, MD, PhD - U of Oklahoma, Oklahoma City, OK |
|
2. Is Cardiac Recovery One of the Reasons CASTLE-AF Worked? Challenges and Opportunities. |
Nassir Marrouche, MD – U of U Health, Salt Lake City, UT |
|
3. From the Great Success of CRT to AF Ablation: What EP Still Needs to do to Make HF Docs Look Great Again. |
Milton Packer, MD- Baylor University Medical Center, Dallas, TX |
Panel discussion (chairs & speakers): How to move the needle: practical recommendations.
11:45am - 12:45pm
Lunch - Posters Viewing
12:45 - 2:45pm
Session 7: Cardiogenic Shock and Recovery
Chairperson: Sean Overton, MD – U of U Health & Joseph Tonna, MD - U of U Health
Cardiogenic shock cases: HF Surgery and HF Cardiology. Antigone Koliopoulou, MD, U of U Health & Line Kemeyou, MD – U of U Health
|
Topic |
Speaker |
|
1. Assessment of Cardiopulmonary Recovery During Short-Term MCS. |
Simon Maybaum, MD – Hofstra/ Northwell Health, Manhasset, NY |
|
2. Advantages and Disadvantages of ECMO and Impella Support Systems. |
Navin K. Kapur, MD - Tufts Medical Center, Boston, MA |
|
3. ECMO, Cardiac Recovery and LV Vent/Unloading: When and How? |
Eduardo Rame, MD – U of Pennsylvania, Philadelphia, PA |
2:45 - 3:00pm
Break
3:00 - 5:00pm
Session 8. Targeted Interactive Discussion: What is the SHOCK Trial study design to advance the field.
Chairperson: Mandeep R. Mehra, MD – Brigham & Women’s/ Harvard & Fred Welt, MD – U of U Health
| A. |
Introduction & Rationale for Options: Stephen McKellar, MD - U of U Health Option 1: “Time for Direct Comparison ECMO vs. Impella?” Option 2: “Short-term MCS Efficacy in Shock Has Not Been Proven -- The Option 3: Other ideas |
| B. | Intensivist’s View re the ideal study design- Alexandre Mebazaa, MD - Hôpital Lariboisière, University of Paris,France |
| C. | HF Cardiologist’s view re the ideal study design- Shelley Hall, MD - Baylor University Medical Center, Dallas, TX |
| D. |
Interventional Cardiologist’s view re the ideal study design - George Dangas, MD - Mount Sinai, New York, NY |
| E. | HF Surgeon’s view re the ideal study design- Carmelo Milano, MD - Duke University, Durham, NC |
Panel Discussion - Chairs and Speakers
Closing Remarks