Nephrology Faculty Research Featured in Nature Genetics
On May 31, 2019, a trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals were published in Nature Genetics, titled as “A catalog of genetic loci associated with kidney function from analyses of a million individuals". Dr. Man Li, PhD, Assistant Professor in the Division of Nephrology & Hypertension was one of the co-first authors. This study identified and characterized a large number of genetic loci associated with eGFR and prioritized potential effector genes, driver variants and target tissues. These findings will help direct functional studies and advance the understanding of kidney function biology, a prerequisite to develop novel therapies to reduce the burden of CKD.
Dr. Man Li is an Assistant Professor in the Department of Medicine, Division of Nephrology and Hypertension. She has a PhD in Epidemiology from the Johns Hopkins University, and a Masters of Science in Statistics from the University of Idaho. She furthered her training as a post-doctoral fellow at Johns Hopkins University and University of Utah. Her primary research interest is kidney and cardiovascular genetic epidemiology. Her research involves identifying novel genomic variants for kidney function and related outcomes, disease-gene associations for end stage renal disease in African Americans, developing epidemiologic and statistical methods for genomic data, improving clinical decision based on individual’s genetic and lifestyle profiles.