Skip to main content

Dr. Tianxin Yang Receives VA Merit Review Grant

Dr. Tiaxin Yang Receives VA Merit Review Grant

Congratulations to Dr. Tianxin Yang, MD, PhD, professor of medicine in the Division of Nephrology & Hypertension, for his new grant from the VA Salt Lake City Healthcare System for his project, "Defining Renal S1P/sPRR/AT1R pathway in salt-sensitive hypertension."

Project Narrative

The incidence of hypertension is increasing, affecting one in three adults in the United States and nearly half the hypertensive cases are salt-sensitive. Despite intensive investigation, the underlying mechanisms of salt sensitivity in essential hypertension remain elusive. (Pro)renin receptor (PRR) is a new member of the renin-angiotensin system and has recently emerged as a key regulator of renal handling of Na+ and water balance, and blood pressure. Protease-mediated cleavage of PRR generates soluble PRR (sPRR), the extracellular domain of this protein. The goal of this proposal is to test the overall hypothesis that site-1 protease-derived sPRR via angiotensin type 1 receptor induces Na+ reabsorption in the distal nephron, contributing to pathogenesis of salt-sensitive hypertension. Overall, this proposal is expected shed light on the enzymatic source and physio-pathological functions of renal sPRR during blood pressure regulation.