Dr. Yan-Ting Shiu Awarded National Institute of Diabetes and Digestive And Kidney Diseases R01
The Division of Nephrology & Hypertension congratulates Dr. Yan-Ting Shiu for her new R01 obtained through the NIH National Institute of Diabetes and Digestive and Kidney Diseases for her project, “Nanotechnology as a therapeutic approach in arteriovenous fistula maturation." This project is funded for $1,750,973 from 7/1/21 - 5/31/25.
Project Overview
A vascular access, such as an arteriovenous fistula (AVF), is a surgically created conduit used to remove and return blood during hemodialysis. A well-functioning vascular access is a mainstay to perform an efficient hemodialysis procedure. Currently the AVF is the most popular vascular access type and yet AVF maturation failure constitutes a large unmet clinical need with no effective treatment or preventive strategies. Our long-term goal is to develop novel therapeutic strategies to prevent AVF maturation failure that can ultimately be safely used in humans.
This R01 grant is a Multiple-PI collaborative project between the Shiu Lab (Contact PI) at the University of Utah and Dr. Edgar Jaimes in the Renal Service at the Memorial Sloan Kettering Cancer Center. This translational project is innovative and significant, as it investigates a novel molecular pathway of AVF maturation failure and uses a novel nanotechnology for treating/preventing this clinical problem. Successful completion of these aims will identify important targets for developing innovative nanomedicine to enhance AVF maturation.