Top Research Publications: August 2020
Note: Names in bold are faculty members in the Department of Internal Medicine.
Cardiovascular Medicine
Badolia, R, Ramadurai, Abel ED, Ferrin P, Taleb I, Shankar TS, Krokidi AT, Navankasattusas S, McKellar SH, Yin M, Kfoury AG, Wever-Pinzon O, Fang JC, Selzman CH, Chaudhuri D, Rutter J, Drakos SG. The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure. Circulation 2020 Jul 21: 142
Abedin Z, Hoerner R, Habboushe J, Lu Y, Kawamoto K, Warner PB, Shields DE, Shah, RU. Implementation of a Fast Healthcare Interoperability Resources-Based Clinical Decision Support Tool for Calculating CHA2DS2-VASc Scores. Circ Cardiovasc Qual Outcomes. 2020;13(2):e006286. doi:10.1161/CIRCOUTCOMES.119.006286
Liu Y, Zhou K, Li J, Agvanian S, Caldaruse A, Shaw S, Hitzeman TC, Shaw RM, Hong TT. In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium Handling Machinery and Cardiac Function. JACC: Basic to Translational Science DOI: 10.1016/j.jacbts.2020.03.006
Endocrinology, Metabolism & Diabetes
Lin YK, Groat D, Chan O, Hung M, Sharma A, Varner MW, Gouripeddi R, Facelli JC, Fisher SJ. Online ahead of print. Associations between the Time in Hypoglycemia and Hypoglycemia Awareness Status in Type 1 Diabetes Patients Using Continuous Glucose Monitoring Systems. Diabetes Technol Ther. 2020 Apr 8. doi: 10.1089/dia.2020.0016.
Xiong X, Menting JG, Disotuar MM, Amith NA, Delaine CA, Ghabash G, Agarwal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH. A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nat Struct Mol Biol. 2020;27(7):683. doi:10.1038/s41594-020-0460-2
Rios M, Wahl MP, Simmons DL, Schlegel A. Skull base lymphoma with panhypopituitarism. Lancet Oncol. 2020;21(8):e405. doi:10.1016/S1470-2045(20)30221-7
Epidemiology
Vanneman ME, Wagner TH, Shwartz M, Meterko M, Francis J, Greenstone CL, Rosen AK. Veterans’ Experiences with Outpatient Care: Comparing the Veterans Affairs System with Community-Based Care. Health Aff (Millwood). 2020 Aug;39(8):1368-1376. doi: 10.1377/hlthaff.2019.01375
Gordon AJ, Drexler K, Hawkins EJ, et al. Stepped Care for Opioid Use Disorder Train the Trainer (SCOUTT) initiative: Expanding access to medication treatment for opioid use disorder within Veterans Health Administration facilities. Subst Abus. 2020;41(3):275-282. doi:10.1080/08897077.2020.1787299
Classen DC, Holmgren AJ, Co Z, et al. National Trends in the Safety Performance of Electronic Health Record Systems From 2009 to 2018. JAMA Netw Open. 2020;3(5):e205547. Published 2020 May 1. doi:10.1001/jamanetworkopen.2020.5547
Gastroenterology, Hepatology & Nutrition
Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E. Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa. Gut. 2020 Jul 8:gutjnl-2020-320946. doi: 10.1136/gutjnl-2020-320946. PMID: 32641470
Gawron AJ, Bell R, Abu Dayyeh BK, Buckley FP, Chang K, Dunst CM, Edmundowicz SA, Jobe B, Lipham JC, Lister D, Canto MI, Smith MS, Starpoli AA, Triadafilopoulos G, Watson TJ, Wilson E, Pandolfino JE, Kaizer A, Van De Voorde Z, Yadlapati R. Surgical and endoscopic management options for patients with GERD based on proton pump inhibitor symptom response: recommendations form an expert U.S. Panel. Gastrointest Endosc. 2020 Jul;92(1):78-87.e2. doi: 10.1016/j.gie.2020.01.037. Epub 2020 Jan 31. PMID: 32007519\
Chandan S, Mohan BP, Khan SR, Bhogal N, Ramai D, Bilal M, Aziz M, Shah AR, Mashiana HS, Jha LK, Bhat I, Singh S, Adler DG. Adenoma and polyp detection rates during insertion versus withdrawal phase of colonoscopy: a systematic review and meta-analysis of randomized controlled trials. Gastrointest Endosc. 2020 Jun 12:S0016-5107(20)34433-3. doi: 10.1016/j.gie.2020.06.015. PMID: 32540312
General Internal Medicine
Lappé KL, Raaum SE, Ciarkowski CE, Reddy SP, Johnson SA Impact of Hospitalist Team Structure on Patient-Reported Satisfaction with Physician Performance. J Gen Intern Med. 2020 Mar 24. doi: 10.1007/s11606-020-05775-5. Online ahead of print.
Doane J, Flynn M, Archibald M, Ramirez D, Conroy MB, Stults B. Unattended automated office blood pressure measurement: Time efficiency and barriers to implementation/utilization. J Clin Hypertens (Greenwich). 2020 Apr;22(4):598-604. doi: 10.1111/jch.13840. Epub 2020 Mar 9.
Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben CJ, Petrey AC, Tolley ND, Guo L, Cody MJ, Weyrich AS, Yost CC, Rondina MT, Campbell RA. Platelet Gene Expression and Function in COVID-19 Patients. Blood. 2020 Jun 23:blood.2020007214. doi: 10.1182/blood.2020007214. Online ahead of print.
Geriatrics
Farrell TW, Ferrante LE, Brown T, Francis L, Widera E, Rhodes R, Rosen T, Hwang U, Witt LJ, Thothala N, Liu SW, Vitale CA, Braun UK, Stephens C, Saliba D. AGS Position Statement: Resource Allocation Strategies and Age-Related Considerations in the COVID-19 Era and Beyond. J Am Geriatr Soc. 2020 Jun;68(6):1136-1142. doi: 10.1111/jgs.16537.PMID: 32374440
Hematology & Hematologic Malignancies
Eide CA, Zabriskie MS, Savage Stevens SL, Antelope O, Vellore NA, Than H, Schultz AR, Clair P, Bowler AD, Pomicter AD, Yan D, Senina AV, Qiang W, Kelley TW, Szankasi P, Heinrich MC, Tyner JW, Rea D, Cayuela JM, Kim DW, Tognon CE, O'Hare T, Druker BJ*, Deininger MW* (*equal contributions). Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy Against Highly Resistant BCR-ABL1 Mutants. Cancer Cell 2019, 36(4):431-443.e5.
Patel AB, Franzini A, Leroy E, Kim SJ, Pomicter A, Genet L, Xiao M, Yan D, Ahmann JM, Agarwal AM, Clair P, Addada J, Lambert J, Salmon M, Gleich GJ, Cross N, Constantinescu SN, O'Hare T, Prchal J, Deininger MW. JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera. Blood. 2019 Dec 26;134(26):2388-2398. doi: 10.1182/blood.2019001385.
Stephens DM, Byrd JC. Next-Generation Bruton tyrosine kinase inhibitors. J Clin Oncol. 2020 Jul 16:JCO2001594. doi: 10.1200/JCO.20.01594. Online ahead of print.
Infectious Diseases
Mellon G, Turbett SE, Worby C, Oliver E, Walker AT, Walters M, Kelly P, Leung DT, Knouse M, Hagmann S, Earl A, Ryan ET, LaRocque RC. Acquisition of Antibiotic-Resistant Bacteria by U.S. International Travelers. N Engl J Med. 2020 Apr 2;382(14):1372-1374.
Verma D, Church TM, Swaminathan, S. Epstein–Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters. Proceedings of the National Academy of Sciences Jun 2020, 117 (23) 13044-13055; DOI: 10.1073/pnas.2000625117
Brintz BJ, Howard J, Haaland B, Platts-Mills JA, Greene T, Levine AC, Nelson EJ, Pavia AT, Kotloff KL, Leung DT. Clinical predictors for etiology of acute diarrhea in children in resource-limited settings. PLoS Negl Trop Dis. In press.
Nephrology & Hypertension
Lakshmipathi J, Gao Y, Hu C, Stuart D, Genzen J, Ramkumar N, Kohan DE: Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2-Mediated Blood Pressure Reduction Independent of Cystogenesis. J Am Soc Nephrol 31:1243-1254, 2020.
Zhang Y, Ecelbarger CM, Lesniewski LA, Müller CE, Kishore BK: P2Y2 Receptor Promotes High-Fat Diet-Induced Obesity. Front Endocrinol 11:341:1-19, 2020.
Ilkun OL, Greene T, Cheung AK, Whelton PK, Wei G, Boucher RE, Ambrosius W, Chertow GM, Beddhu S: The Influence of Baseline Diastolic Blood Pressure on the Effects of Intensive Blood Pressure Lowering on Cardiovascular Outcomes and All-Cause Mortality in Type 2 Diabetes. Diabetes Care 43:1878-1884, 2020. Editorial: https://care.diabetesjournals.org/content/43/8/1684 and podcast: https://www.diabetesjournals.org/content/diabetes-core-update-podcasts
Oncology
Swami U, Isaacsson Velho P, Nussenzveig R, Chipman J, Santos VS, Erickson S, Dharmaraj D, Alva AS, Vaishampayan UN, Esther J, Hahn AW, Maughan BL, Antonarakis ES, Agarwal N. Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer [published online ahead of print, 2020 Jul 2]. Eur Urol. 2020;S0302-2838(20)30462-0. doi:10.1016/j.eururo.2020.06.033
de Bono J, Mateo J, Fizazi K, Saad F, Shore N, Sandhu S, Chi KN, Sarton O, Agarwal N, Olmos D, Thiery-Vuillemin A, Twardowski P, Mehra N, Goessl C, Kang J, Burgents J, Wu W, Kohlmann A, Adelman CA, Hussain M. Olaparib for Metastatic Castration-Resistant Prostate Cancer. N Engl J Med. 2020;382(22):2091-2102. doi:10.1056/NEJMoa1911440
Agarwal N, Nussenzveig R, Hahn AW, Hoffman, JM, Morton K, Gupta S, Batten J, Thorley J, Hawks J, Santos VS, Nachaegari G, Wang X, Boucher K, Haaland B, Maughan BL. Prospective Evaluation of Bone Metabolic Markers as Surrogate Markers of Response to Radium-223 Therapy in Metastatic Castration-resistant Prostate Cancer. Clin Cancer Res. 2020;26(9):2104-2110. doi:10.1158/1078-0432.CCR-19-2591
Respiratory, Critical Care & Occupational Pulmonary Medicine
Maddock SD, Cirulis MM, Callahan SJ, Keenan LM, Pirozzi CS, Raman SM, Aberegg SK. Pulmonary Lipid-Laden Macrophages and Vaping. N Engl J Med. 2019 Oct 10;381(15):1488-1489.
Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris E, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC. Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome. Blood. 2020 Jun 29:blood.2020007008.
Brown SM, Peltan ID, Webb B, Kumar N, Starr N, Grissom C, Buckel WR, Srivastava R, Harris ES, Leither LM, Johnson SA, Paine R 3rd, Greene T. Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial. Ann Am Thorac Soc. 2020 Aug;17(8):1008-1015. doi: 10.1513/AnnalsATS.202004-309SD.
Rheumatology
Rodriguez-Pla A, Warner RL, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford CA, Moreland LW, Pagnoux C, Seo P, Specks U, Sreih, AG, Ytterberg SR, Johnson KJ, Merkel PA. Evaluation of Potential Serum Biomarkers of Disease Activity in Diverse Forms of Vasculitis. J Rheumatol. 2020;47(7):1001-1010. doi:10.3899/jrheum.190093
Thomas J, Radic M, Tucker JR, Overbury R, Frech T. Raynaud's phenomenon in Systemic Sclerosis: Does Digital Thermal Monitoring Correlate to Specific Nailfold Videocapillaroscopy Abnormalities? J Rheumatol. 2020 Jun 15:jrheum.191371. doi: 10.3899/jrheum.191371.
Walsh JA, Pei S, Penmetsa GK, Overbury R, Clegg DO, Sauer B. (In Press). Identifying axial spondyloarthritis patients in large datasets: Expanding possibilities for observational research. J Rheum.