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Top Research Publications: February 2021

Top Research Publications: February 2021

Note: Names in bold are faculty members in the Department of Internal Medicine.

Cardiovascular Medicine

Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Ry TV, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab. 2020 Dec 11;S1550-4131(20)30658-6. doi: 10.1016/j.cmet.2020.12.003. PMID: 33333007.

Khan MS, Yamashita K, Sharma V, Ranjan R, Dosdal DJ. RNAs and Gene Expression Predicting Postoperative Atrial Fibrillation in Cardiac Surgery Patients Undergoing Coronary Artery Bypass Grafting. Journal of Clinical Medicine. 2020 April;9(4):1139. Doi: 10.3390/jcm9041139. PMID: 32316120.

Waldron, J. A Guide for the Diagnosis and Management of Amyloidosis. AAHFN; 2020. Chapter 6, Device Therapies in Cardiac Amyloidosis; p. 59 - 66.

Endocrinology, Metabolism & Diabetes

Sejling AS, Wang P, Zhu W, Farhat R, Knight N, Appadurai D, Chan O. Repeated Activation of Noradrenergic Receptors in the Ventromedial Hypothalamus Suppresses the Response to Hypoglycemia. Endocrinology. 2021 Mar 1;162(3):bqaa241. doi: 10.1210/endocr/bqaa241. PMID: 33367607.

Delaney A, Burkholder AB, Lavender CA, Plummer L, Mericq V, Merino PM, Quinton R, Lewis KL, Meader BN, Albano A, Shaw ND, Welt CK, Martin KA, Seminara SB, Biesecker LG, Bailey-Wilson JE, Hall JE. Increased Burden of Rare Sequence Variants in GnRH-Associated Genes in Women with Hypothalamic Amenorrhea. J Clin Endocrinol Metab. 2020 Sep 1:dgaa609. doi: 10.1210/clinem/dgaa609. Online ahead of print. PMID: 32870266.


Madaras-Kelly K, Hostler C, Townsend M, Potter EM, Spivak ES, Hall SK, Goetz MB, Nevers M, Ying J, Haaland B, Rovelsky SA, Pontefract B, Fleming-Dutra K, Hicks LA, Samore MH. Impact of Implementation of the Core Elements of Outpatient Antibiotic Stewardship within Veterans Health Administration Emergency Department and Primary Care Clinics on Antibiotic Prescribing and Patient Outcomes. Clin Infect Dis. 2020 Dec 8:ciaa1831. doi: 10.1093/cid/ciaa1831. Online ahead of print. PMID: 33289028.

Lynch KE, Gatsby E, Viernes B, Schliep KC, Whitcomb BW, Alba PR, DuVall SL, Blosnich JR. Evaluation of Suicide Mortality Among Sexual Minority US Veterans From 2000 to 2017. JAMA Netw Open. 2020 Dec 1;3(12):e2031357. doi: 10.1001/jamanetworkopen.2020.31357. PMID: 33369662.

Gaglio B, Henton M, Barbeau A, Evans E, Hickam D, Newhouse R, Zickmund S. Methodological standards for qualitative and mixed methods patient centered outcomes research. BMJ. 2020 Dec 23;371:m4435. doi: 10.1136/bmj.m4435. PMID: 33361103.

Gastroenterology, Hepatology & Nutrition

Syal G, Robbins L, Kashani A, Bonthala N, Feldman E, Fleshner P, Vasiliauskas E, McGovern D, Ha C, Targan S, Melmed GY. Hypoalbuminemia and Bandemia Predict Failure of Infliximab Rescue Therapy in Acute Severe Ulcerative Colitis. Dig Dis Sci. 2021 Jan;66(1):199-205. doi: 10.1007/s10620-020-06177-7. Epub 2020 Mar 13. PMID: 32170473.

Gawron AJ, Staub J, Bielefeldt K. Impact of Health Insurance, Poverty, and Comorbidities on Colorectal Cancer Screening: Insights from the Medical Expenditure Panel Survey. Dig Dis Sci. 2021 Jan;66(1):70-77. doi: 10.1007/s10620-020-06541-7. Epub 2020 Aug 20. PMID: 32816210.

General Internal Medicine

Incze MA. At the Cusp - Reimagining Infective Endocarditis Care amid the Opioid Epidemic. N Engl J Med. 2021 Jan 28;384(4):297-299. doi: 10.1056/NEJMp2032066. Epub 2021 Jan 23. PMID: 33503690.

Vaughn VM, Gandhi TN, Chopra V, Petty LA, Giesler DL, Malani AN, Bernstein SJ, Hsaiky LM, Pogue JM, Dumkow L, Ratz D, McLaughlin ES, Flanders SA. Antibiotic Overuse after Hospital Discharge: A Multi-Hospital Cohort Study. Clin Infect Dis. 2020 Sep 11:ciaa1372. doi: 10.1093/cid/ciaa1372. Epub ahead of print. PMID: 32918077.


Islam MT, Henson GD, Machin DR, Bramwell RC, Donato AJ, Lesniewski LA. Aging differentially impacts vasodilation and angiogenesis in arteries from the white and brown adipose tissues. Exp Gerontol. 2020 Dec;142: 111126. PMID: 33203620.

Machin DR, Auduong Y, Gogulamudi VR, Liu Y, Islam MT, Lesniewski LA, Donato AJ. Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age. Aging. 2020 Jun 20;12(12): 11314-11324. PMID: 32564006.

Farrell TW, Francis L, Lundebjerg N. The Later Innings of Life: Implications of COVID-19 Resource Allocation Strategies for Older Adults. Journal of the American Geriatrics Society. 2020 Dec;68(12): 2714-2715. PMID: 33038008.

Hematology & Hematologic Malignancies 

Ferreira Dos Santos MC, Anderson CP, Neschen S, Zumbrennen-Bullough KB, Romney SJ, Kahle-Stephan M, Rathkolb B, Gailus-Durner V, Fuchs H, Wolf E, Rozman J, Hrabe de Angelis M, Cai WM, Rajan M, Hu J, Dedon PC, Leibold EA. Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA Nat Commun. 2020 Jan 15;11(1):296. PMID: 31941883.

Stephens DM, Boucher K, Kander E, Parikh SA, Parry EM, Shadman M, Pagle JM, Cooperrider J, Rhodes J, Mato A, Winter A, Hill B, Gaballa S, Danilov A, Phillips T, Brander DM, Smith SM, Davids M, Rogers K, Glenn MJ, Byrd JC. Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: Outcomes from a large multi-center collaboration, Haematologica. 2020 Oct 5;Online ahead of print. doi:10.3324/haematol.2020.256388. PMID: 33054118.

Lim MY, Cheng D, Recht M, Kempton CL, Key NS. Inhibitors and mortality in persons with nonsevere hemophilia A in the United States. Blood Adv. 2020;4(19):4739-4747. PMCID: PMC7556148. PMID: 33007074.

Infectious Diseases

Trevas T, Caliendo AM, Hanson K, Levy J, Ginocchio CC. Diagnostic Tests Can Stem the Threat of Antimicrobial Resistance: Infectious Disease Professionals Can Help. Clinical Infectious Disease. 2020 Nov 18;ciaa1527. doi: 10.1093/cid/ciaa1527. PMID: 33206946.

Carlson V, Dekeyser, G, Certain L, Pupaibool J, Gililland J, Anderson AA. Clinical Experience With a Coordinated Multidisciplinary Approach to Treating Prosthetic Joint Infection. Athroplast Today. 2020 Jun 12;6(3):360-362. Doi: 10.1016/ eCollection 2020 Sep. 18;ciaa1527. doi: 10.1093/cid/ciaa1527. PMID: 32566717.

Hubbard L, Iriana S, Carey A, Odrobina R, Sossenheimer M, Rogers D. Radiographic and Endoscopic Features of Pancreaticoduodenal Malakoplakia. Pancreas. 2020 Mar;49(3):455-460. Doi:10.1097/MPA.0000000000001497. PMID:32168251.

Nephrology & Hypertension

Pleinis JM, Norrell L, Akella R, Humphreys JM, He H, Sun Q, Zhang F, Sosa-Pagan J, Morrison DE, Schellinger JN, Jackson LK, Goldsmith EJ, Rodan, AR. WNKs are potassium-sensitive kinases. Am J Physiol Cell Physiol. 2021 Jan 13. doi: 10.1152/ajpcell.00456.2020. Online ahead of print. PMID: 33439774.

Molnar MZ, Bhalla A, Azhar A, Tsujita M, Talwar M, Balaraman V, Sodhi A, Kadaria D, Eason JD, Hayek SS, Coca SG, Shaefi S, Neyra JA, Gupta S, Leaf DE, Kovesdy CP; STOP-COVID Investigators. Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States. Am J Transplant. 2020 Nov;20(11):3061-3071. doi: 10.1111/ajt.16280. Epub 2020 Sep 15. PMID: 32844546. PMCID: PMC7460925.

Gosse P, Cremer A, Kirtane AJ, Lobo MD, Saxena M, Daemen J, Wang Y, Stegbauer J, Weber MA, Abraham J, Kario K, Bangalore S, Claude L, Liu Y, Azizi M. Ambulatory Blood Pressure Monitoring to Predict Response to Renal Denervation: A Post Hoc Analysis of the RADIANCE-HTN SOLO Study. Hypertension. 2021 Feb;77(2):529–536. Originally published 28 Dec 2020. Doi: 10.1161/HYPERTENSIONAHA.120.16292. PMID: 33356403.


Goldkorn A, Tangen CM, Plets M, Morrison GJ, Cunha A, Xu T, Pinski J, Ingles SA, Triche TJ, Harzstark A, Kohli M, MacVicar GR, Vaena D, Crispino AW, McConkey DJ, Lara PN, Hussain M, Quinn DI, Vogelzang NJ, Thompson IM, Agarwal N. Baseline circulating tumor cell count as a prognostic marker of PSA response and disease progression in metastatic castrate sensitive prostate cancer (SWOG S1216). Clin Cancer Res. 2021 Jan 26;clincanres.3587.2020. doi: 10.1158/1078-0432.CCR-20-3587. Online ahead of print. PMID: 33500355.

Pokorny R, McPherson JP, Haaland B, Grossmann KF, Luckett C, Voorhies BN, Sageser DS, Wallentine J, Tolman Z, Hu-Lieskovan S, Swami U. Real-world experience with elective discontinuation of PD-1 inhibitors at 1 year in patients with metastatic melanoma. J Immunother Cancer. 2021 Jan;9(1):e001781. doi: 10.1136/jitc-2020-001781. PMID: 33500258.

McKay RR, McGregor BA, Xie W, Braun DA, Wei X, Kyriakopoulos CE, Zakhaira Y, Maughan BL, Rose TL, Stadler WM, McDermott DF, Harshman LC, Choueiri TK. Optimized Management of Nivolumab and Ipilimumab in Advanced Renal Cell Carcinoma: A Response-Based Phase II Study (OMNIVORE). J Clin Oncol. 2020 Dec 20;38(36):4240-4248. doi: 10.1200/JCO.20.02295. Epub 2020 Oct 27. PMID: 33108238.

Respiratory, Critical Care & Occupational Pulmonary Medicine

Liou TG, Adler FR, Cahill BC, Cox DR, Cox JE, Grant GJ, Hanson KE, Hartsell SC, Hatton ND, Helms MN, Jensen JL, Kartsonaki C, Li Y, Leung DT, Marvin JE, Middleton EA, Osburn-Staker SM, Packer KA, Shakir SM, Sturrock AB, Tardif KD, Warren KJ, Waddoups LJ, Weaver LJ, Zimmerman E, Paine R. SARS-CoV-2 Innate Effector Associations and Viral Load in Early Nasopharyngeal Infection. Physiological Reports, in press 2021. PMID: 33173878.

Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT. Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood. 2019 Sep 19;134(12):911-923. doi: 10.1182/blood.2019000067. Epub 2019 Jul 31.PMID: 31366617.

Liou TG, Adler FR, Hatton ND. The Uncertain Role of Corticosteroids in the Treatment of COVID-19. JAMA Intern Med. 2021 Jan 1;181(1):139-140. doi: 10.1001/jamainternmed.2020.2438. PMID: 32744622.


Frech TM, VanBuren JM, Startup E, Assassi S, Bernstein EJ, Castelino FV, Chung L, Correia C, Gordon JK, Hant FN, Hummers L, Khanna D, Sandorfi N, Shah AA, Shanmugam VK, Steen V, Evnin L. Does hand involvement in systemic sclerosis limit completion of patient-reported outcome measures? Clin Rheumatol. 2020 Oct 23. doi: 10.1007/s10067-020-05467-9. Online ahead of print. PMID: 33094395.

Walsh JA, Magrey MN, Baraliakos X, Inui K, Weng MY, Lubrano E, van der Heijde D, Boonen A, Gensler LS, Strand V, Braun J, Hunter T, Li X, Zhu B, León L, Marcelino Sandoval Calderon D, Kiltz U. Ixekizumab Improves Functioning and Health in the Treatment of Active Non-Radiographic Axial Spondyloarthritis: 52-Week Results, COAST-X Trial. Arthritis Care Res (Hoboken). 2020 Oct 12. PMID: 33044756.